It is shown how acquisition of He-3 affects Lunar Base development and operation. A four phase evolutionary Lunar Base scenario is summarized with initial equipment mass and resupply requirements. Requirements for various He-3 mining operations are shown and available by-products are identified. Impacts of mining He-3 on Lunar Base development include increases in equipment masses to be delivered to the lunar surface and a reduction of Lunar Base resupply based on availability of He-3 acquisition by-products. It is concluded that the acquisition of this valuable fusion fuel element greatly enhances the commercial potential of a Lunar Base.